Malegra 50 mg works by enhancing the body’s natural response to sexual arousal. During sexual activity, nitric oxide is released in the penis, which helps produce a substance called cGMP. cGMP plays a crucial role in relaxing the smooth muscles and dilating the blood vessels, leading to increased blood flow. However, the body naturally breaks down cGMP with the help of PDE5. Sildenafil, the active ingredient in Malegra 50 mg, inhibits PDE5, allowing cGMP to remain active for a longer period, thereby maintaining the erection.